Structure of PDB 6trx Chain A

Receptor sequence
>6trxA (length=843) Species: 9606 (Homo sapiens) [Search protein sequence]
LEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSD
RIYYLAMSGENRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQYSREEEL
LRERKRIGTVGIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRP
NLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHN
ELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYE
ENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEG
RIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQI
VLISPELFIPVEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFH
VFPQSHEEEIEFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDF
KCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYV
VSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSS
PEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPH
DLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDN
RGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGW
SYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQ
GYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKP
YDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKV
3D structure
PDB6trx Aerosol-based ligand soaking of reservoir-free protein crystals.
ChainA
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y669 S755 Y756 D833 H865
Catalytic site (residue number reindexed from 1) Y615 S701 Y702 D779 H811
Enzyme Commision number 3.4.14.5: dipeptidyl-peptidase IV.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9XH A R160 E275 E276 Y669 S755 Y756 V781 W784 Y787 Y791 N835 V836 R106 E221 E222 Y615 S701 Y702 V727 W730 Y733 Y737 N781 V782 BindingDB: IC50=14nM
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0008239 dipeptidyl-peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0043069 negative regulation of programmed cell death
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6trx, PDBe:6trx, PDBj:6trx
PDBsum6trx
PubMed34188616
UniProtQ6V1X1|DPP8_HUMAN Dipeptidyl peptidase 8 (Gene Name=DPP8)

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