Structure of PDB 6tr7 Chain A

Receptor sequence
>6tr7A (length=350) Species: 9606 (Homo sapiens) [Search protein sequence]
DLRLHLLLNTSVTCNDGSPAGYYLKESRGSRRWLLFLEGGWYCFNRENCD
SRYDTMRRLMSSRDWPRTRTGTGILSSQPEENPYWWNANMVFIPYCSSDV
WSGASSKSEKNEYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAGGTG
VLLNVDRVAEQLEKLGYPAIQVRGLADSGWFLDNKQYRHTDTITAPTEAI
RRGIRYWNGVVPERCRRQFQEGEEWNCFFGYKVYPTLRSPVFVVQWLFDE
AQLTVDNVHLPVQEGLRLYIQNLGRELRHTLKDVPASFAPACLSHEIIIR
SHWTDVQVKGTSLPRALHCWDRSLHTPLKGCPVHLVDSCPWPHCNPSCPT
3D structure
PDB6tr7 Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum.
ChainA
Resolution1.47 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.1.98: [Wnt protein] O-palmitoleoyl-L-serine hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HWH A Y129 A233 T236 F268 P287 F319 F320 V346 Y42 A146 T149 F181 P196 F228 F229 V255 MOAD: ic50=37uM
BindingDB: IC50=37200nM
BS02 HWH A D270 N271 P287 D183 N184 P196 MOAD: ic50=37uM
BindingDB: IC50=37200nM
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:6tr7, PDBe:6tr7, PDBj:6tr7
PDBsum6tr7
PubMed31876313
UniProtQ6P988|NOTUM_HUMAN Palmitoleoyl-protein carboxylesterase NOTUM (Gene Name=NOTUM)

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