Structure of PDB 6tq7 Chain A

Receptor sequence
>6tq7A (length=301) Species: 9606 (Homo sapiens) [Search protein sequence]
YAWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFLVNLSLADVL
ATAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDR
WYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAA
RTRAFSVCDERWADDLAPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWG
RQIPGTTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGM
FRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSWW
L
3D structure
PDB6tq7 Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis.
ChainA
Resolution2.6636 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NVK A P123 Q126 A127 M176 Q179 T223 P79 Q82 A83 M132 Q135 T179 BindingDB: IC50=40nM,Ki=14nM
BS02 NVK A S103 Q126 V130 T223 Y311 I314 S315 H344 Y348 S59 Q82 V86 T179 Y235 I238 S239 H268 Y272 BindingDB: IC50=40nM,Ki=14nM
BS03 PGW A L230 M233 A234 Q237 L186 M189 A190 Q193
BS04 PGW A V177 P178 W206 C218 F219 V133 P134 W162 C174 F175
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0016499 orexin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007631 feeding behavior
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6tq7, PDBe:6tq7, PDBj:6tq7
PDBsum6tq7
PubMed31860301
UniProtO43613|OX1R_HUMAN Orexin/Hypocretin receptor type 1 (Gene Name=HCRTR1)

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