Structure of PDB 6tq6 Chain A

Receptor sequence
>6tq6A (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
EDEFLRYLWRDYLYPKQYAWVLIAAYVAVFVVALVGNTLVCLAVWRNHHM
RTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQA
VSVSVAVLTLSFIALDRWYAICHPLLFKSTARRALGSILGIWAVSLAIMV
PQAAVMECSSFSVCDERWADDLAPKIYHSCFFIVTYLAPLGLMAMAYFQI
FRKLWGQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFRQASD
REAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSW
3D structure
PDB6tq6 Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis.
ChainA
Resolution2.546 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NVH A S103 W112 I122 P123 Q126 Q179 F219 I314 N318 S76 W85 I95 P96 Q99 Q152 F181 I232 N236 BindingDB: Ki=16nM
BS02 PGW A A174 P178 A181 Y215 C218 A147 P151 A154 Y177 C180
BS03 PGW A S138 W145 L230 M233 A234 Q237 S111 W118 L192 M195 A196 Q199
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0016499 orexin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007631 feeding behavior
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6tq6, PDBe:6tq6, PDBj:6tq6
PDBsum6tq6
PubMed31860301
UniProtO43613|OX1R_HUMAN Orexin/Hypocretin receptor type 1 (Gene Name=HCRTR1)

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