Structure of PDB 6tq4 Chain A

Receptor sequence
>6tq4A (length=297) Species: 9606 (Homo sapiens) [Search protein sequence]
ASEDEFLRYLWRDYLYPKQYAWVLIAAYVAVFVVALVGNTLVCLAVWRNH
HMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYL
QAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRALGSILGIWAVSLAI
MVPQAAVMECSSVFSVCDERWADDLAPKIYHSCFFIVTYLAPLGLMAMAY
FQIFRKLWVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMFR
QASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSW
3D structure
PDB6tq4 Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis.
ChainA
Resolution2.299 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NV8 A C99 I122 P123 Q126 Q179 F219 I314 N318 C74 I97 P98 Q101 Q154 F184 I236 N240 BindingDB: Ki=79nM
BS02 PGW A S138 W145 L230 M233 A234 Q237 S113 W120 L195 M198 A199 Q202
BS03 PGW A A174 V177 A181 Y215 A149 V152 A156 Y180
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0016499 orexin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007631 feeding behavior
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6tq4, PDBe:6tq4, PDBj:6tq4
PDBsum6tq4
PubMed31860301
UniProtO43613|OX1R_HUMAN Orexin/Hypocretin receptor type 1 (Gene Name=HCRTR1)

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