Structure of PDB 6tp6 Chain A

Receptor sequence
>6tp6A (length=305) Species: 9606 (Homo sapiens) [Search protein sequence]
AASEDEFLRYLWRDYLYPKQYAWVLIAAYVAVFVVALVGNTLVCLAVWRN
HHMRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPY
LQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRALGSILGIWAVSLA
IMVPQAAVMECSSVLAFSVCDERWADDLAPKIYHSCFFIVTYLAPLGLMA
MAYFQIFRKLWTSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLK
RVFGMFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQFKA
AFSWW
3D structure
PDB6tp6 Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis.
ChainA
Resolution2.338 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NT5 A A102 S103 I122 P123 Q126 Q179 Y311 I314 N318 H344 A78 S79 I98 P99 Q102 Q155 Y240 I243 N247 H273 BindingDB: Ki=2.5nM,IC50=16nM
BS02 PGW A S138 W145 A226 M233 A234 Q237 S114 W121 A194 M201 A202 Q205
BS03 PGW A A174 V177 P178 A181 Y215 A150 V153 P154 A157 Y183
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0016499 orexin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007631 feeding behavior
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6tp6, PDBe:6tp6, PDBj:6tp6
PDBsum6tp6
PubMed31860301
UniProtO43613|OX1R_HUMAN Orexin/Hypocretin receptor type 1 (Gene Name=HCRTR1)

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