Structure of PDB 6tp4 Chain A

Receptor sequence
>6tp4A (length=298) Species: 9606 (Homo sapiens) [Search protein sequence]
EDEFLRYLWRDYLYPKQYAWVLIAAYVAVFVVALVGNTLVCLAVWRNHHM
RTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQA
VSVSVAVLTLSFIALDRWYAICHPLLFKSTARRALGSILGIWAVSLAIMV
PQAAVMECSSVFSVCDERWADDLAPKIYHSCFFIVTYLAPLGLMAMAYFQ
IFRKLWSAEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMF
RQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSW
3D structure
PDB6tp4 Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis.
ChainA
Resolution3.011 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NRZ A S103 I122 P123 Q179 F219 S315 N318 S76 I95 P96 Q152 F182 S238 N241 BindingDB: IC50=60nM,Ki=6.3nM
BS02 PGW A S138 M233 A234 Q237 S111 M196 A197 Q200
BS03 PGW A A174 V177 P178 W206 C218 A147 V150 P151 W169 C181
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0016499 orexin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007631 feeding behavior
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6tp4, PDBe:6tp4, PDBj:6tp4
PDBsum6tp4
PubMed31860301
UniProtO43613|OX1R_HUMAN Orexin/Hypocretin receptor type 1 (Gene Name=HCRTR1)

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