Structure of PDB 6tot Chain A

Receptor sequence
>6totA (length=300) Species: 9606 (Homo sapiens) [Search protein sequence]
SEDEFLRYLWRDYLYPKQYAWVLIAAYVAVFVVALVGNTLVCLAVWRNHH
MRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQ
AVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRALGSILGIWAVSLAIM
VPQAAVMECSSVRAFSVCDERWADDLAPKIYHSCFFIVTYLAPLGLMAMA
YFQIFRKLWEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGM
FRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSWW
3D structure
PDB6tot Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis.
ChainA
Resolution2.22 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NRK A S103 P123 Q126 I314 H344 S77 P97 Q100 I238 H268 BindingDB: Ki=2.5nM
BS02 PGW A A174 A181 C218 A148 A155 C184
BS03 PGW A S138 M233 Q237 S112 M199 Q203
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0016499 orexin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007631 feeding behavior
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6tot, PDBe:6tot, PDBj:6tot
PDBsum6tot
PubMed31860301
UniProtO43613|OX1R_HUMAN Orexin/Hypocretin receptor type 1 (Gene Name=HCRTR1)

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