Structure of PDB 6tos Chain A

Receptor sequence
>6tosA (length=302) Species: 9606 (Homo sapiens) [Search protein sequence]
SEDEFLRYLWRDYLYPKQYAWVLIAAYVAVFVVALVGNTLVCLAVWRNHH
MRTVTNYFLVNLSLADVLATAICLPASLLVDITESWLFGHALCKVIPYLQ
AVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRALGSILGIWAVSLAIM
VPQAAVMECSSVRAFSVCDERWADDLAPKIYHSCFFIVTYLAPLGLMAMA
YFQIFRKLWGEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFG
MFRQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSW
WL
3D structure
PDB6tos Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis.
ChainA
Resolution2.13 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NRE A A102 S103 P123 Q126 A127 Q179 F219 H344 A76 S77 P97 Q100 A101 Q153 F185 H269 BindingDB: Ki=2.0nM
BS02 PGW A A174 V177 P178 Y215 C218 A148 V151 P152 Y181 C184
BS03 PGW A S138 M233 A234 Q237 S112 M199 A200 Q203
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0016499 orexin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007631 feeding behavior
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6tos, PDBe:6tos, PDBj:6tos
PDBsum6tos
PubMed31860301
UniProtO43613|OX1R_HUMAN Orexin/Hypocretin receptor type 1 (Gene Name=HCRTR1)

[Back to BioLiP]