Structure of PDB 6tol Chain A

Receptor sequence
>6tolA (length=130) Species: 9606 (Homo sapiens) [Search protein sequence]
LYFQGADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTV
LMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFCILLDFMYTSRLNLRE
GNIMAVMATAMYLQMEHVVDTCRKFIKASE
3D structure
PDB6tol AchievingIn VivoTarget Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders.
ChainA
Resolution1.64 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NQW A M51 A52 C53 G55 Y58 Q113 E115 M52 A53 C54 G56 Y59 Q114 E116 MOAD: ic50=0.15uM
BindingDB: IC50=150nM
External links
PDB RCSB:6tol, PDBe:6tol, PDBj:6tol
PDBsum6tol
PubMed32275432
UniProtP41182|BCL6_HUMAN B-cell lymphoma 6 protein (Gene Name=BCL6)

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