Structure of PDB 6toj Chain A

Receptor sequence
>6tojA (length=131) Species: 9606 (Homo sapiens) [Search protein sequence]
NLYFQGADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKT
VLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFCILLDFMYTSRLNLR
EGNIMAVMATAMYLQMEHVVDTCRKFIKASE
3D structure
PDB6toj AchievingIn VivoTarget Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NQQ A M51 A52 C53 G55 Y58 Q113 M114 E115 M53 A54 C55 G57 Y60 Q115 M116 E117 MOAD: ic50=0.86uM
BindingDB: IC50=860nM
External links
PDB RCSB:6toj, PDBe:6toj, PDBj:6toj
PDBsum6toj
PubMed32275432
UniProtP41182|BCL6_HUMAN B-cell lymphoma 6 protein (Gene Name=BCL6)

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