Structure of PDB 6toi Chain A

Receptor sequence
>6toiA (length=125) Species: 9606 (Homo sapiens) [Search protein sequence]
ADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACS
GLFYSIFTDQLKCNLSVINLDPEINPEGFCILLDFMYTSRLNLREGNIMA
VMATAMYLQMEHVVDTCRKFIKASE
3D structure
PDB6toi AchievingIn VivoTarget Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders.
ChainA
Resolution1.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I9 Q10 F11 T12 I5 Q6 F7 T8
BS02 NQN A M51 A52 C53 G55 Y58 Q113 E115 M47 A48 C49 G51 Y54 Q109 E111 MOAD: ic50=1.7uM
BindingDB: IC50=1700nM
External links
PDB RCSB:6toi, PDBe:6toi, PDBj:6toi
PDBsum6toi
PubMed32275432
UniProtP41182|BCL6_HUMAN B-cell lymphoma 6 protein (Gene Name=BCL6)

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