Structure of PDB 6tog Chain A

Receptor sequence
>6togA (length=124) Species: 9606 (Homo sapiens) [Search protein sequence]
DSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSG
LFYSIFTDQLKCNLSVINLDPEINPEGFCILLDFMYTSRLNLREGNIMAV
MATAMYLQMEHVVDTCRKFIKASE
3D structure
PDB6tog AchievingIn VivoTarget Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders.
ChainA
Resolution1.69 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A C8 I9 Q10 F11 T12 C3 I4 Q5 F6 T7
BS02 NQH A M51 A52 C53 S54 G55 Y58 M46 A47 C48 S49 G50 Y53 MOAD: ic50=207uM
BindingDB: IC50=207000nM
External links
PDB RCSB:6tog, PDBe:6tog, PDBj:6tog
PDBsum6tog
PubMed32275432
UniProtP41182|BCL6_HUMAN B-cell lymphoma 6 protein (Gene Name=BCL6)

[Back to BioLiP]