Structure of PDB 6tod Chain A

Receptor sequence
>6todA (length=301) Species: 9606 (Homo sapiens) [Search protein sequence]
YAWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFLVNLSLADVL
ATAICLPASLLVDITESWLFGHALCKVIPYLQTVSVSVAVLTLSFIALDR
WYAICHPLLFKSTARRALGSILGIWAVSLAIMVPQAAVMECSSVLPELAA
RTRAFSVCDERWADDLAPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWG
RQIPGTTSEVKQMRARRKTAKMLMVVVLVFALCYLPISVLNVLKRVFGMF
RQASDREAVYAAFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSWWL
P
3D structure
PDB6tod Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis.
ChainA
Resolution2.11 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7MA A P123 Q126 T127 V130 Q179 F219 I314 N318 H344 V347 Y348 P79 Q82 T83 V86 Q135 F175 I237 N241 H267 V270 Y271 BindingDB: Ki=900nM,IC50=>10000nM
BS02 PGW A L230 M233 F236 Q237 R240 L186 M189 F192 Q193 R196
BS03 PGW A A174 V177 A181 Y215 C218 A130 V133 A137 Y171 C174
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0016499 orexin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007631 feeding behavior
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:6tod, PDBe:6tod, PDBj:6tod
PDBsum6tod
PubMed31860301
UniProtO43613|OX1R_HUMAN Orexin/Hypocretin receptor type 1 (Gene Name=HCRTR1)

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