Structure of PDB 6to2 Chain A

Receptor sequence
>6to2A (length=406) Species: 247156 (Nocardia farcinica IFM 10152) [Search protein sequence]
CPHSDTLTIDPMITDLAGETSRLRAAGPLTRIDLLGVPALAVTGHTLARQ
LLTDTRLVKDINAWSLWQSGTVTRQWPLIGMIDVDRSMFTVDGPEHRRLR
IKTTQALTRRRLDALKPTIERYVAELLDDLERAGADGAVVDLKSVFAYPL
PMRVISALMGVPSEDQEQLLTWYKAFFSILTPQDERLRVIDEMHGYFTEM
VRRKTAEPGDDLTSALIYATDGETPLTEEEVIGNLQALVAAGHETTVSLI
LTAVRALLSHPEQLRLVRDGEIGWETAIEETLRWDGPVIHLLMRFATEDI
DLGDAVIPRGEGVVMSYRAIGRDITVHGADADDFDITRATAARHISFGHG
PHICPGAALARLEAAIALPALFTRFPHLHPALPLDQIPNLPVLTQNDLSH
FPIHLG
3D structure
PDB6to2 CYP154C5 Regioselectivity in Steroid Hydroxylation Explored by Substrate Modifications and Protein Engineering*.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S181 E247 T248 C357 P358 G359
Catalytic site (residue number reindexed from 1) S178 E244 T245 C354 P355 G356
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A M91 H99 R103 A244 G245 T248 T249 P290 L294 R297 Y320 S349 F350 H355 C357 P358 A363 M88 H96 R100 A241 G242 T245 T246 P287 L291 R294 Y317 S346 F347 H352 C354 P355 A360
BS02 NQ8 A M84 F92 A240 A244 M81 F89 A237 A241 MOAD: Kd=20nM
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:6to2, PDBe:6to2, PDBj:6to2
PDBsum6to2
PubMed33145893
UniProtQ5YNS8

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