Structure of PDB 6tlq Chain A

Receptor sequence
>6tlqA (length=240) Species: 9606 (Homo sapiens) [Search protein sequence]
TEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMW
ERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCR
AYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEI
ALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLHKTHRQSILAKLP
PKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS
3D structure
PDB6tlq Cooperativity between the orthosteric and allosteric ligand binding sites of ROR gamma t.
ChainA
Resolution1.761 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR A Q286 C320 M365 L483 F486 Q19 C53 M98 L216 F219 BindingDB: EC50=20nM
BS02 MJE A L324 T325 I328 Q329 M358 Q484 A496 A497 F498 L501 Y502 L505 F506 L57 T58 I61 Q62 M91 Q217 A229 A230 F231 L234 Y235 L238 F239
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6tlq, PDBe:6tlq, PDBj:6tlq
PDBsum6tlq
PubMed33536342
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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