Structure of PDB 6tl2 Chain A

Receptor sequence
>6tl2A (length=494) Species: 908337 (Eremococcus coleocola ACS-139-V-Col8) [Search protein sequence]
DLSLSDINSTVEVPEGHSFWKTLLAYSGPGALVAVGYMDPGNWSTSITGG
QNFQYLLLSIIVISSLLAMLLQNMAAKLGIVCQLDLAQAIRARTSRRLGF
IFWILTELAIMATDIAEVIGAAIALYLLFKIPIFLAVVITVLDVFLLLLL
NRIGFRKIEALVVCLIFVILFVFLYQIILSQPAWHQVAKGLIPSWASVQT
SPKIGGQTPLSASLGIIGATIMPHNLFLHSAISQSRKIDRTDSSKVAEAV
RFSNWDSNIQLSLAMVVNALLLIMGVAVFKSGAVQDPSFFGLYQALSNPD
MVSNPVLAEAARSGVLSTLFAVALLASGQNSTITGTITGQVIMEGFIHLR
LPLWLRRLVTRLIAIIPVVVCVAITSHQGSLDEHQALNNLMNNSQVFLAL
ALPFSIVPLLMLTDSAAQMGNQFKNTRWVKVMGWLTVIILTLLNLISISS
QIAGFFGDNPSSQDLLLSQVISIGIILAMIGLLIWTIIDIRRFT
3D structure
PDB6tl2 Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds.
ChainA
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NJZ A D51 N54 A231 L410 S459 D39 N42 A219 L398 S447 PDBbind-CN: -logKd/Ki=5.44,Ki=3.6uM
Gene Ontology
Molecular Function
GO:0005384 manganese ion transmembrane transporter activity
GO:0015086 cadmium ion transmembrane transporter activity
GO:0015293 symporter activity
GO:0046872 metal ion binding
GO:0046873 metal ion transmembrane transporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0030001 metal ion transport
GO:0055085 transmembrane transport
GO:0070574 cadmium ion transmembrane transport
GO:0071281 cellular response to iron ion
GO:0071421 manganese ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6tl2, PDBe:6tl2, PDBj:6tl2
PDBsum6tl2
PubMed31804182
UniProtE4KPW4

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