Structure of PDB 6tiz Chain A

Receptor sequence
>6tizA (length=430) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSGDDSFNTFFSET
GAGKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARG
HYTIGKEIVDLVLDRIRKLADQCTGLQGFLIFHSFGGGTGSGFTSLLMER
LSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDN
EAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQ
TNLVPYPRIHFPLVTYAPVISAEYHEQLSVAEITNACFEPANQMVKCDPR
HGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQ
PPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWY
VGEGMEEGEFSEAREDLAALEKDYEEVGMD
3D structure
PDB6tiz GTP-dependent formation of straight tubulin oligomers leads to microtubule nucleation.
ChainA
Resolution2.197 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP A G10 Q11 A12 Q15 A99 N101 S140 G143 G144 T145 G146 V177 T179 E183 N206 Y224 N228 G10 Q11 A12 Q15 A93 N95 S134 G137 G138 T139 G140 V171 T173 E177 N200 Y218 N222
Gene Ontology
Molecular Function
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0007017 microtubule-based process
GO:0032418 lysosome localization
Cellular Component
GO:0000235 astral microtubule
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005819 spindle
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6tiz, PDBe:6tiz, PDBj:6tiz
PDBsum6tiz
PubMed33544140
UniProtP06603|TBA1_DROME Tubulin alpha-1 chain (Gene Name=alphaTub84B)

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