Structure of PDB 6thq Chain A

Receptor sequence
>6thqA (length=297) Species: 999630 (Thermoproteus uzoniensis 768-20) [Search protein sequence]
GSMKVWLDGRLVDEEEAKVTVLSPSLNYGFGVFEGIRAYWNGENLYVFRL
RDHMERLLRSAKIIGLDVPYTAEELSKAVVETVRANGFKEDLYIRPVAYI
SKPQISLDVRGLQASVAIAAIPFGKYLKVEGVRAAVVSWRRVHTSMMPVM
AKATGIYLNSIMAAVEARARGYDEAIMLNAEGKVVEGSGENIFIVRRGVL
MTPPLEDGILEGITRETVISIAGDLGIPLLEKSITREELYAADEAFFVGT
AAEITPIIEIDGRVLQRGPITQKIAETYRRIVLGKEEKYLPWLTPVY
3D structure
PDB6thq Three-Dimensional Structure of Branched-Chain Amino Acid Transaminase from Thermoproteus uzoniensis in Complex with L-Norvaline
ChainA
Resolution2.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F31 K150 E184 L208
Catalytic site (residue number reindexed from 1) F33 K152 E186 L210
Enzyme Commision number 2.6.1.42: branched-chain-amino-acid transaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A R54 K150 Y155 E184 L208 G210 I211 T212 T248 R56 K152 Y157 E186 L210 G212 I213 T214 T250
BS02 PY5 A R54 Y91 K150 Y155 E184 S186 G187 E188 N189 G210 I211 T212 G247 T248 A249 R56 Y93 K152 Y157 E186 S188 G189 E190 N191 G212 I213 T214 G249 T250 A251
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004084 branched-chain-amino-acid transaminase activity
GO:0008483 transaminase activity
GO:0052654 L-leucine-2-oxoglutarate transaminase activity
GO:0052655 L-valine-2-oxoglutarate transaminase activity
GO:0052656 L-isoleucine-2-oxoglutarate transaminase activity
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009081 branched-chain amino acid metabolic process
GO:0009082 branched-chain amino acid biosynthetic process
GO:0009097 isoleucine biosynthetic process
GO:0009098 L-leucine biosynthetic process
GO:0009099 L-valine biosynthetic process
GO:0019752 carboxylic acid metabolic process
GO:0046394 carboxylic acid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6thq, PDBe:6thq, PDBj:6thq
PDBsum6thq
PubMed
UniProtF2L0W0

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