Structure of PDB 6tez Chain A

Receptor sequence

>6tezA (length=697) Species: 9606 (Homo sapiens) [Search protein sequence]

PVNPEKLLVITVATAETEGYLRFLRSAEFFNYTVRTLGLGEEWRGGDTVG
GGQKVRWLKKEMEKYADREDMIIMFVDSYDVILAGSPTELLKKFVQSGSR
LLFSAESFCWPEWGLAEQYPEVGTGKRFLNSGGFIGFATTIHQIVRQWKY
KDDDDDQLFYTRLYLDPGLREKLSLNLDHKSRIFQNLNGALDEVVLKFDR
NRVRIRNVAYDTLPIVVHGNGPTKLQLNYLGNYVPNGWTPEGGCGFCNQD
RQPPPRVFLAVFVEQPTPFLPRFLQRLLLLDYPPDRVTLFLHNNEVFHEP
HIADSWPQLQDHFSAVKLVGPEEALSPGEARDMAMDLCRQDPECEFYFSL
DADAVLTNLQTLRILIEENRKVIAPMLSRHGKLWSNFWGALSPDEYYARS
EDYVELVQRKRVGVWNVPYISQAYVIRGDTLRMELPQRDVFSGSDTDPDM
AFCKSFRDKGIFLHLSNQHEFGRLLATSRYDTEHLHPDLWQIFDNPVDWK
EQYIHENYSRALEGEGIVEQPCPDVYWFPLLSEQMCDELVAEMEHYGQWS
GGRHEDSRLAGGYENVPTVDIHMKQVGYEDQWLQLLRTYVGPMTESLFPG
YHTKARAVMNFVVRYRPDEQPSLRPHHDSSTFTLNVALNHKGLDYEGGGC
RFLRYDCVISSPRKGWALLHPGRLTHYHEGLPTTWGTRYIMVSFVDP

3D structure

PDB

6tez Identification of Regulatory Molecular 'Hot Spots' for LH/PLOD Collagen Glycosyltransferase Activity

Chain

Resolution

2.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.14.11.4: procollagen-lysine 5-dioxygenase.
2.4.1.50: procollagen galactosyltransferase.
2.4.1.66: procollagen glucosyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	UGA	A	V44 A45 T46 W75 T83 G85 D112 Y114 D115 W145 H253 K259	V12 A13 T14 W43 T48 G50 D77 Y79 D80 W110 H218 K224
BS02	AKG	A	R599 Y656 L664 H667 N676 C691 H719 R729 V733	R558 Y615 L623 H626 N635 C650 H678 R688 V692
BS03	FE2	A	H667 D669 H719	H626 D628 H678
BS04	FE2	A	H595 D597 D611 H613 F652	H554 D556 D570 H572 F611
BS05	MN	A	D112 D115 H253	D77 D80 H218

Gene Ontology

	Molecular Function
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0008475	procollagen-lysine 5-dioxygenase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016757	glycosyltransferase activity
GO:0031418	L-ascorbic acid binding
GO:0033823	procollagen glucosyltransferase activity
GO:0036094	small molecule binding
GO:0046872	metal ion binding
GO:0050211	procollagen galactosyltransferase activity
GO:0051213	dioxygenase activity

	Biological Process
GO:0001701	in utero embryonic development
GO:0001886	endothelial cell morphogenesis
GO:0006493	protein O-linked glycosylation
GO:0008104	protein localization
GO:0017185	peptidyl-lysine hydroxylation
GO:0021915	neural tube development
GO:0030199	collagen fibril organization
GO:0032963	collagen metabolic process
GO:0042311	vasodilation
GO:0046947	hydroxylysine biosynthetic process
GO:0048730	epidermis morphogenesis
GO:0060425	lung morphogenesis
GO:0070831	basement membrane assembly

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005789	endoplasmic reticulum membrane
GO:0005791	rough endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0016020	membrane
GO:0062023	collagen-containing extracellular matrix
GO:0070062	extracellular exosome

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6tez, PDBe:6tez, PDBj:6tez
PDBsum	6tez
PubMed
UniProt	O60568\|PLOD3_HUMAN Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (Gene Name=PLOD3)

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