Structure of PDB 6tdh Chain A

Receptor sequence
>6tdhA (length=164) Species: 330879 (Aspergillus fumigatus Af293) [Search protein sequence]
ENTPLFSPSLISPDVLAVLPADYTIRPLCRSDYKRGYLDVLRVLTTVGDI
NEEQWNSRYEWIRARSDEYYLLVVCDGEGRIVGTGSLVVERKFHSLGMVG
HIEDIAVEKGQQGKKLGLRIIQALDYVAEKVGCYKTILDCSEANEGFYIK
CGFKRAGLEMAHYY
3D structure
PDB6tdh Targeting a critical step in fungal hexosamine biosynthesis.
ChainA
Resolution1.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.4: glucosamine-phosphate N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACO A V68 I131 A132 V133 Q138 G139 K141 G143 L144 N170 G172 F173 Y174 K176 V43 I105 A106 V107 Q112 G113 K115 G117 L118 N144 G146 F147 Y148 K150
BS02 N2Z A V113 H127 V88 H101 MOAD: Kd=6uM
Gene Ontology
Molecular Function
GO:0004343 glucosamine 6-phosphate N-acetyltransferase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
Biological Process
GO:0006048 UDP-N-acetylglucosamine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6tdh, PDBe:6tdh, PDBj:6tdh
PDBsum6tdh
PubMed32341126
UniProtQ4WCU5

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