Structure of PDB 6tdc Chain A

Receptor sequence
>6tdcA (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
SHMESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMN
SLMMGEDKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTL
LKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPK
FEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQAL
ELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHP
LLQEIYKDLY
3D structure
PDB6tdc Binding of PPAR(gamma) to MRL871
ChainA
Resolution2.328 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4F1 A F310 C313 Q314 R316 I354 L358 M362 I369 S370 F391 M392 K395 F396 H477 F65 C68 Q69 R71 I109 L113 M117 I124 S125 F146 M147 K150 F151 H232 BindingDB: IC50=130nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6tdc, PDBe:6tdc, PDBj:6tdc
PDBsum6tdc
PubMed
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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