Structure of PDB 6tc6 Chain A

Receptor sequence
>6tc6A (length=252) Species: 996307 (Neisseria meningitidis alpha522) [Search protein sequence]
PELPEVETTLRGIAPHIEGKTVEAVVLRQLKLRWQINPDLGEILSGRQVL
SCGRRAKYLLIRFQTGVLLIHLGMSGSLRIFTPSDGRIGRPDRHDHVDIV
FSDGTVMRYRDPRKFGAILWYEGIEEHHPLLEKLGPEPLSEAFCADYLYA
RLKAQKRAVKLALMDNAVVVGVGNIYANESLFRAGISPHRPANRLKKKEC
ALLVETVKAVLQRAIETYTYGRHNQPCPRCGGLVVKETLGQRGTFYCPNC
QK
3D structure
PDB6tc6 Conformational changes of DNA repair glycosylase MutM triggered by DNA binding.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.23: DNA-formamidopyrimidine glycosylase.
4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C250 C253 C270 C273 C227 C230 C247 C250
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0008270 zinc ion binding
GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity
GO:0016787 hydrolase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0016829 lyase activity
GO:0019104 DNA N-glycosylase activity
GO:0034039 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
GO:0046872 metal ion binding
GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6tc6, PDBe:6tc6, PDBj:6tc6
PDBsum6tc6
PubMed32598485
UniProtI4E596

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