Structure of PDB 6t88 Chain A

Receptor sequence

>6t88A (length=454) Species: 211586 (Shewanella oneidensis MR-1)

MEYTYDVVIIGSGGAGFSAGLEAIAAGRSAVIIEKMPIIGGNSLISGAEM
NVAGSWVQKNMGITDSKELFISDTLKGGDFKGDPEMVKTMVDNAVGAAEW
LRDYVKVEFYPDQLFQFGGHSVKRALIPKGHTGAEVISKFSIKADEVGLP
IHTNTKAEKLIQDQTGRIVGVEAAHNGKTITYHAKRGVVIATGGFSSNME
MRKKYNPELDERYGSTGHAGGTGDGIVMAEKIHAAAKNMGYIQSYPICSP
TSGAIALIADSRFFGAVLINQKGERFVEELERRDVISHAILAQPGRYTYV
LWNQDIENVAHTVEMHQGELKEFTKDGLMYKVDTLEEAAKVFNIPEDKLL
STIKDVNHYAATGKDEAFNHRSGLVDLSKGPYWILKATPSVHHTMGGLVV
DTRTRVLDEQGKVIPGLFAAGEVTGLTHGTNRLGGNAYTDIIVYGRIAGQ
EAAK

3D structure

• PDB: 6t88 Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production.
• Chain: A
• Resolution: 1.4 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): F245 Q371 Y373 A384 A387 R390 R411 H520 H521 R560
• Catalytic site (residue number reindexed from 1): F117 Q243 Y245 A256 A259 R262 R283 H392 H393 R432
• Enzyme Commision number: 1.3.99.33: urocanate reductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	I138 G139 G141 A143 E162 K163 G169 N170 S171 S174 G175 A176 E177 A285 T320 G321 T344 H346 D352 H520 H521 G549 E550 G563 A565 Y566 I569	I10 G11 G13 A15 E34 K35 G41 N42 S43 S46 G47 A48 E49 A157 T192 G193 T216 H218 D224 H392 H393 G421 E422 G435 A437 Y438 I441
BS02	MWQ	A	E177 F245 Y373 L385 D388 H520 R560 G562	E49 F117 Y245 L257 D260 H392 R432 G434

Gene Ontology

Molecular Function

• GO:0010181 FMN binding
• GO:0016491 oxidoreductase activity

External links

• PDB: RCSB:6t88, PDBe:6t88, PDBj:6t88
• PDBsum: 6t88
• PubMed: 33649331
• UniProt: Q8CVD0|URDA_SHEON Urocanate reductase (Gene Name=urdA)