Structure of PDB 6t7p Chain A

Receptor sequence
>6t7pA (length=237) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLP
LQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQ
APLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNI
PLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMW
RLVGITSWGEGCARREQPGVYTKVAEYMDWILEKTQS
3D structure
PDB6t7p Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach.
ChainA
Resolution1.416 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 K192 G193 D194 S195
Catalytic site (residue number reindexed from 1) H44 D93 K185 G186 D187 S188
Enzyme Commision number 3.4.21.34: plasma kallikrein.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GSH A W29 P120 C122 M206 W207 W14 P111 C113 M199 W200
BS02 MU8 A L41 H57 D189 A190 C191 K192 G193 S195 W215 G216 G219 L28 H44 D182 A183 C184 K185 G186 S188 W208 G209 G211 MOAD: Ki=0.97uM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6t7p, PDBe:6t7p, PDBj:6t7p
PDBsum6t7p
PubMed32551603
UniProtP03952|KLKB1_HUMAN Plasma kallikrein (Gene Name=KLKB1)

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