Structure of PDB 6t7k Chain A

Receptor sequence
>6t7kA (length=494) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
NILGITSKKIENFSDWYTQVIVKSELIEYYDISGCYILRPAAYYIWECVQ
AFFNKEIKKLNVENSYFPLFVTKNKLEKEKNHIEGFSPEVAWVTKYGDSN
LPEEIAIRPTSETIMYSVFPKWIRSYRDLPLKLNQWNTVVRWEFKQPTPF
IRTREFLWQEGHTAHKNEEEAVKLVFDILDLYRRWYEEYLAVPIIKGIKS
EGEKFGGANFTSTAEAFISENGRAIQAATSHYLGTNFAKMFKIEFEDENE
VKQYVHQTSWGCTTRSIGIMIMTHGDDKGLVLPPNVSKYKVVIVPIFYKT
DENAIHSYCKDIEKILKNAQINCVYDDRASYSPGYKFNHWELRGIPIRIE
VGPKDLQNNSCVIVRRDNNEKCNVKKESVLLETQQMLVDIHKNLFLKAKK
KLDDSIVQVTSFSEVMNALNKKKMVLAPWCEDIATEEEIKKETQRLSLTN
SETTLSGAMKPLCIPLDQPPMPPNMKCFWSGKPAKRWCLFGRSY
3D structure
PDB6t7k Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium falciparum in complex with NCP-26 and L-Proline
ChainA
Resolution1.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.15: proline--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PRO A T359 E361 W407 E409 H411 F454 H480 S508 W509 G510 T110 E112 W158 E160 H162 F205 H231 S259 W260 G261
BS02 MU5 A R390 E392 K394 F399 I400 R401 T402 F405 T512 R514 R141 E143 K145 F150 I151 R152 T153 F156 T263 R265
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004827 proline-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006433 prolyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6t7k, PDBe:6t7k, PDBj:6t7k
PDBsum6t7k
PubMed
UniProtQ8I5R7|SYP_PLAF7 Proline--tRNA ligase (Gene Name=proRS)

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