Structure of PDB 6t77 Chain A

Receptor sequence
>6t77A (length=244) Species: 573 (Klebsiella pneumoniae) [Search protein sequence]
MSFEGKIALVTGASRGIGRAIAETLVARGAKVIGTATSESGAQAISDYLG
ANGKGLMLNVTDPASIESVLENVRAEFGEVDILVNNAGITRDNLLMRMKD
DEWNDIIETNLSSVFRLSKAVMRAMMKKRHGRIITIGSVVGTMGNAGQAN
YAAAKAGLIGFSKSLAREVASRGITVNVVAPGFIETDMTRALTDEQRAGT
LAAVPAGRLGTPNEIASAVAFLASDEASYITGETLHVNGGMYMV
3D structure
PDB6t77 A FabG inhibitor targeting an allosteric binding site inhibits several orthologs from Gram-negative ESKAPE pathogens.
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G16 S138 Y151
Catalytic site (residue number reindexed from 1) G16 S138 Y151
Enzyme Commision number 1.1.1.100: 3-oxoacyl-[acyl-carrier-protein] reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A G12 S14 R15 T37 L58 N59 V60 A87 G88 I89 G12 S14 R15 T37 L58 N59 V60 A87 G88 I89
Gene Ontology
Molecular Function
GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0051287 NAD binding
Biological Process
GO:0006633 fatty acid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6t77, PDBe:6t77, PDBj:6t77
PDBsum6t77
PubMed33388594
UniProtW9B6I8

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