Structure of PDB 6t50 Chain A

Receptor sequence
>6t50A (length=241) Species: 9606 (Homo sapiens) [Search protein sequence]
LTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEM
WERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMC
RAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDE
IALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLHKTHRQSILAKL
PPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS
3D structure
PDB6t50 Cooperativity between the orthosteric and allosteric ligand binding sites of ROR gamma t.
ChainA
Resolution1.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 HC3 A Q286 M365 H479 Q20 M99 H213 BindingDB: EC50=20nM
BS02 MJE A L324 T325 I328 Q329 K354 Q484 A496 A497 F498 Y502 L505 F506 L58 T59 I62 Q63 K88 Q218 A230 A231 F232 Y236 L239 F240
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:6t50, PDBe:6t50, PDBj:6t50
PDBsum6t50
PubMed33536342
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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