Structure of PDB 6t4x Chain A

Receptor sequence
>6t4xA (length=241) Species: 9606 (Homo sapiens) [Search protein sequence]
LTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEM
WERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMC
RAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDE
IALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLHKTHRQSILAKL
PPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS
3D structure
PDB6t4x Cooperativity between the orthosteric and allosteric ligand binding sites of ROR gamma t.
ChainA
Resolution1.48 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HC3 A Q286 M365 H479 Q20 M99 H213 BindingDB: EC50=20nM
BS02 L3E A L324 T325 I328 Q329 L353 K354 M358 L483 Q484 A496 A497 F498 Y502 L505 F506 L58 T59 I62 Q63 L87 K88 M92 L217 Q218 A230 A231 F232 Y236 L239 F240
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6t4x, PDBe:6t4x, PDBj:6t4x
PDBsum6t4x
PubMed33536342
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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