Structure of PDB 6t4u Chain A

Receptor sequence
>6t4uA (length=240) Species: 9606 (Homo sapiens) [Search protein sequence]
TEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMW
ERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCR
AYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEI
ALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLHKTHRQSILAKLP
PKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS
3D structure
PDB6t4u Cooperativity between the orthosteric and allosteric ligand binding sites of ROR gamma t.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HCD A Q286 M365 F388 H479 Q19 M98 F121 H212
BS02 4F1 A L324 T325 I328 Q329 K354 M358 L483 Q484 Q487 A496 A497 F498 L501 Y502 L505 F506 L57 T58 I61 Q62 K87 M91 L216 Q217 Q220 A229 A230 F231 L234 Y235 L238 F239 BindingDB: IC50=7.8nM,EC50=16nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:6t4u, PDBe:6t4u, PDBj:6t4u
PDBsum6t4u
PubMed33536342
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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