Structure of PDB 6t4g Chain A

Receptor sequence
>6t4gA (length=241) Species: 9606 (Homo sapiens) [Search protein sequence]
LTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEM
WERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMC
RAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDE
IALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLHKTHRQSILAKL
PPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS
3D structure
PDB6t4g Cooperativity between the orthosteric and allosteric ligand binding sites of ROR gamma t.
ChainA
Resolution1.93 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR A Q286 C320 M365 L483 Q20 C54 M99 L217 BindingDB: EC50=20nM
BS02 L3E A L324 T325 Q329 L353 K354 L483 Q484 Q487 A496 A497 F498 Y502 F506 L58 T59 Q63 L87 K88 L217 Q218 Q221 A230 A231 F232 Y236 F240
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6t4g, PDBe:6t4g, PDBj:6t4g
PDBsum6t4g
PubMed33536342
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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