Structure of PDB 6t3w Chain A

Receptor sequence
>6t3wA (length=208) Species: 12072 (Coxsackievirus B3) [Search protein sequence]
KCRIEPVCLLLHGSPGAGKSVATNLIGRSLAEKLNSSVYSLPPDPDHFDG
YKQQAVVIMDDLCQNPDGKDVSLFCQMVSSVDFVPPMAALEEKGILFTSP
FVLASTNAGSINAPTVSDSRALARRFHFDMNIEVISMYSQNGKINMPMSV
KTCCPVNFKKCCPLVCGKAIQFIDRRTQVRYSLDMLVTEMFREYNHRHSV
GTTLEALF
3D structure
PDB6t3w Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex.
ChainA
Resolution1.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C269 C281 C286 C153 C161 C166
BS02 SFX A L178 C179 P182 D186 F190 L238 L62 C63 P66 D70 F74 L122
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:6t3w, PDBe:6t3w, PDBj:6t3w
PDBsum6t3w
PubMed34985963
UniProtP03313|POLG_CXB3N Genome polyprotein

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