Structure of PDB 6t2k Chain A

Receptor sequence
>6t2kA (length=343) Species: 9606 (Homo sapiens) [Search protein sequence]
DLRLHLLLNTSVTCNDGSPAGYYLKESRGSRRWLLFLEGGWYCFNRENCD
SRYDTMRRLMSSRDWPRTRTGTGILSSQPEENPYWWNANMVFIPYCSSDV
WSGASSKSEKNEYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAGGTG
VLLNVDRVAEQLEKLGYPAIQVRGLADSGWFLDNKQYRHAPTEAIRRGIR
YWNGVVPERCRRQFQEGEEWNCFFGYKVYPTLRSPVFVVQWLFDEAQLTV
DNVHVQEGLRLYIQNLGRELRHTLKDVPASFAPACLSHEIIIRSHWTDVQ
VKGTSLPRALHCWDRSLHTPLKGCPVHLVDSCPWPHCNPSCPT
3D structure
PDB6t2k Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors.
ChainA
Resolution1.38 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.1.98: [Wnt protein] O-palmitoleoyl-L-serine hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 M9K A G127 W128 S232 A233 F268 P287 F319 F320 H389 G40 W41 S145 A146 F181 P191 F223 F224 H288
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:6t2k, PDBe:6t2k, PDBj:6t2k
PDBsum6t2k
PubMed31862412
UniProtQ6P988|NOTUM_HUMAN Palmitoleoyl-protein carboxylesterase NOTUM (Gene Name=NOTUM)

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