Structure of PDB 6t1v Chain A

Receptor sequence
>6t1vA (length=268) Species: 9606 (Homo sapiens) [Search protein sequence]
DLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGE
DKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNL
DLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKP
FGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDI
QDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKT
ETDMSLYPLLQEIYKDLY
3D structure
PDB6t1v Structure of a PPARg mutant complex
ChainA
Resolution2.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K329 V343 L346 P495 L496 E499 K92 V106 L109 P258 L259 E262
BS02 EDK A F310 G312 C313 Q314 S317 H351 I369 F391 M392 H477 Y501 F73 G75 C76 Q77 S80 H114 I132 F154 M155 H240 Y264 BindingDB: EC50=130nM,Ki=0.049700nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6t1v, PDBe:6t1v, PDBj:6t1v
PDBsum6t1v
PubMed
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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