Structure of PDB 6t0r Chain A

Receptor sequence

>6t0rA (length=701) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10)))

MENFVRTNFNPMILERAEKTMKEYGENPQNEGNKFAAISTHMEVCFMYSD
FHFIDLEGNTIVKMLKHRFEIIEGQERNIAWTIVNSICNMTENSKPRFLP
DLYDYKTNKFIEIGVTRRKVEDYYYEKASKLKGENVYIHIFSFDGEEMAT
DDEYILDEESRARIKTRLFVLRQELATAGLWDSFRQSEEEEFSYPPTFQR
LANQSLPPSFKDYHQFKAYVSSFKANGNIEAKLGAMSEKVNAQIESFDPR
TIRELELPEGKFCTQRSKFLLMDAMKLSVLNPAHEGEGIPMKDAKACLDT
FWGWKKATIIKKHEKGVNTNYLMIWEQLLESIKEMEGKFLNLKKTNHLKW
GLGEGQAPEKMDFEDCKEVPDLFQYKSEPPEKRKLASWIQSEFNKASELT
NSNWIEFDELGNDVAPIEHIASRRRNFFTAEVSQCRASEYIMKAVYINTA
LLNSSCTAMEEYQVIPIITKCRDTSGQRRTNLYGFIIKGRSHLRNDTDVV
NFISLEFSLTDPRNEIHKWEKYCVLEIGDMEIRTSISTIMKPVYLYVRTN
GTSKIKMKWGMEMRRCLLQSLQQVESMIEAESAVKEKDMTEPFFRNREND
WPIGESPQGIEKGTIGKVCRVLLAKSVFNSIYASAQLEGFSAESRKLLLL
IQAFRDNLDPGTFDLKGLYEAIEECIINDPWVLLNASWFNSFLKAVQLSM
G

3D structure

• PDB: 6t0r A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
• Chain: A
• Resolution: 2.82 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	E300 G301 I302 H326 K328 F352 G366 G368 Q369 A370 P371 E372 K373 Y388 S390 P392 P393 E419 Y459 T462 N466 S467 T470 Q476 K483 R485 R503 H505 R507 N508 D511 V512 N514 K534 R561 T562 N563 G564 K569 R577	E287 G288 I289 H313 K315 F339 G353 G355 Q356 A357 P358 E359 K360 Y375 S377 P379 P380 E406 Y446 T449 N453 S454 T457 Q463 K470 R472 R490 H492 R494 N495 D498 V499 N501 K521 R548 T549 N550 G551 K556 R564

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0046872 metal ion binding

Biological Process

• GO:0039694 viral RNA genome replication
• GO:0075523 viral translational frameshifting

External links

• PDB: RCSB:6t0r, PDBe:6t0r, PDBj:6t0r
• PDBsum: 6t0r
• PubMed: 32304664
• UniProt: H6QM92