Structure of PDB 6szm Chain A

Receptor sequence
>6szmA (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
RTVARDITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETEL
YNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLD
TVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCC
IADLGLAVMHSNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVL
WEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRW
FSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKID
3D structure
PDB6szm Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma.
ChainA
Resolution1.42 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.30: receptor protein serine/threonine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 M2Z A R202 V204 A205 R206 W227 R1 V3 A4 R5 W26
BS02 M2Z A W227 I266 W26 I65
BS03 M2Z A V214 A233 K235 L281 T283 Y285 H286 G289 D293 L343 A353 D354 V13 A32 K34 L80 T82 Y84 H85 G88 D92 L142 A152 D153
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6szm, PDBe:6szm, PDBj:6szm
PDBsum6szm
PubMed32787083
UniProtQ04771|ACVR1_HUMAN Activin receptor type-1 (Gene Name=ACVR1)

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