Structure of PDB 6szj Chain A

Receptor sequence
>6szjA (length=279) Species: 9606 (Homo sapiens) [Search protein sequence]
AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLTPLLD
SERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELL
HRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNE
FHVKIADFGLGTIIYMPPENYEPGQSIKHDIYSYAVITWEVLSRKQPFED
VTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERP
SFLKCLIELEPVLRTFEEITFLEAVIQLK
3D structure
PDB6szj Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors.
ChainA
Resolution2.53 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D146 Q150 N151 D164
Catalytic site (residue number reindexed from 1) D139 Q143 N144 D157
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 M5W A V32 A45 V46 K47 L79 I93 T95 Y97 M98 L153 V28 A41 V42 K43 L72 I86 T88 Y90 M91 L146 PDBbind-CN: -logKd/Ki=5.82,IC50=1.5uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6szj, PDBe:6szj, PDBj:6szj
PDBsum6szj
PubMed31749904
UniProtO43353|RIPK2_HUMAN Receptor-interacting serine/threonine-protein kinase 2 (Gene Name=RIPK2)

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