Structure of PDB 6sxr Chain A

Receptor sequence

>6sxrA (length=481) Species: 1033177 (Aspergillus luchuensis IFO 4308)

MGPCDIYEAGDTPCVAAHSTTRALYSSFSGALYQLQRGSDDTTTTISPLT
AGGIADASAQDTFCANTTCLITIIYDQSGNGNHLTQAPPGGFDGPDTDGY
DNLASAIGAPVTLNGQKAYGVFMSPGTGYRNNEATGTATGDEAEGMYAVL
DGTHYNDACCFDYGNAETSSTDTGAGHMEAIYLGNSTTWGYGAGDGPWIM
VDMQNNLFSGADEGYNSGDPSISYRFVTAAVKGGADKWAIRGANAASGSL
STYYSGARPDYSGYNPMSKEGAIILGIGGDNSNGAQGTFYEGVMTSGYPS
DDTENSVQENIVAAKYVVGSLVSGPSFTSGEVVSLRVTTPGYTTRYIAHT
DTTVNTQVVDDDSSTTLKEEASWTVVTGLANSQCFSFESVDTPGSYIRHY
NFELLLNANDGTKQFHEDATFCPQAALNGEGTSLRSWSYPTRYFRHYENV
LYAASNGGVQTFDSKTSFNNDVSFEIETAFA

3D structure

• PDB: 6sxr Rational Design of Mechanism-Based Inhibitors and Activity-Based Probes for the Identification of Retaining alpha-l-Arabinofuranosidases.
• Chain: A
• Resolution: 1.64 Å

Enzymatic activity

• Enzyme Commision number: 3.2.1.55: non-reducing end alpha-L-arabinofuranosidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	KHP	A	Y359 H463 Y464 E465 N466 D488	Y342 H446 Y447 E448 N449 D471
BS02	KHP	A	H416 Y417 N418 F419 D435	H399 Y400 N401 F402 D418
BS03	KHP	A	C176 M195 D219 Q221 N222 N223 G296 D297	C159 M178 D202 Q204 N205 N206 G279 D280

Gene Ontology

Molecular Function

• GO:0016798 hydrolase activity, acting on glycosyl bonds
• GO:0046556 alpha-L-arabinofuranosidase activity

Biological Process

• GO:0019566 arabinose metabolic process
• GO:0031221 arabinan metabolic process
• GO:0031222 arabinan catabolic process
• GO:0045490 pectin catabolic process
• GO:0045493 xylan catabolic process
• GO:0046373 L-arabinose metabolic process

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:6sxr, PDBe:6sxr, PDBj:6sxr
• PDBsum: 6sxr
• PubMed: 32053363
• UniProt: Q8NK89|ABFB_ASPKW Alpha-L-arabinofuranosidase B (Gene Name=abfB)