Structure of PDB 6sus Chain A

Receptor sequence

>6susA (length=258) Species: 257313 (Bordetella pertussis Tohama I) [Search protein sequence]

ITGDAQANVLRGAGGADVLAGGEGDDVLLGGDGDDQLSGDAGRDRLYGEA
GDDWFFQDAANAGNLLDGGDGRDTVDFSGAKGVFLSLGKGFASLMDEPET
SNVLRNIENAVGSARDDVLIGDAGANVLNGLAGNDVLSGGAGDDVLLGDE
GSDLLSGDAGNDDLFGGQGDDTYLFGVGYGHDTIYESGGGHDTIRINAGA
DQLWFARQGNDLEIRILGTDDALTVHDWYRDADHRVEIIHAANQAVDQAG
IEKLVEAM

3D structure

PDB

6sus Continuous Assembly of beta-Roll Structures Is Implicated in the Type I-Dependent Secretion of Large Repeat-in-Toxins (RTX) Proteins.

Chain

Resolution

1.76 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

4.6.1.1: adenylate cyclase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CA	A	D1413 Q1415 N1417 G1430 G1431 E1432 D1435	D4 Q6 N8 G21 G22 E23 D26
BS02	CA	A	G1431 E1432 G1433 D1435 G1448 A1450 D1453	G22 E23 G24 D26 G39 A41 D44
BS03	CA	A	D1449 A1450 G1451 D1453 N1470 N1473	D40 A41 G42 D44 N61 N64
BS04	CA	A	S1530 R1532 D1534 G1547 L1548 A1549 D1552	S113 R115 D117 G130 L131 A132 D135
BS05	CA	A	L1548 A1549 G1550 D1552 G1565 E1567 D1570	L131 A132 G133 D135 G148 E150 D153
BS06	CA	A	D1566 G1568 D1570 G1583 G1584 Q1585 D1588	D149 G151 D153 G166 G167 Q168 D171
BS07	CA	A	G1584 G1586 D1588 E1603 G1605 D1609	G167 G169 D171 E186 G188 D192
BS08	CA	A	G1606 D1609 R1652 E1654	G189 D192 R235 E237
BS09	CA	A	D1575 A1576 G1577 D1579 Y1596 D1599	D158 A159 G160 D162 Y179 D182
BS10	CA	A	G1557 A1558 G1559 D1561 G1574 A1576 D1579	G140 A141 G142 D144 G157 A159 D162
BS11	CA	A	D1539 G1541 N1543 G1556 G1557 A1558 D1561	D122 G124 N126 G139 G140 A141 D144
BS12	CA	A	A1422 G1424 D1426 G1439 G1440 D1441 D1444	A13 G15 D17 G30 G31 D32 D35
BS13	CA	A	G1440 D1441 G1442 D1444 G1457 E1458 A1459 D1462	G31 D32 G33 D35 G48 E49 A50 D53
BS14	CA	A	E1458 G1460 D1462 G1477 G1478 D1479 D1482	E49 G51 D53 G68 G69 D70 D73
BS15	CA	A	G1478 G1480 D1482 N1523 E1525	G69 G71 D73 N106 E108

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding

View graph for
Molecular Function

External links

PDB	RCSB:6sus, PDBe:6sus, PDBj:6sus
PDBsum	6sus
PubMed	32860773
UniProt	P0DKX7\|CYAA_BORPE Bifunctional hemolysin/adenylate cyclase (Gene Name=cya)

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