Structure of PDB 6suo Chain A

Receptor sequence
>6suoA (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]
GSHMALSLTADQMVSALLDAEPPILYSEYEASMMGLLTNLADRELVHMIN
WAKRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLL
LDRNQGKSVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVY
TEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMS
NKGMEHLYSMPSYDLLLEMLDAHRLHAP
3D structure
PDB6suo Building Bridges in a Series of Estrogen Receptor Degraders: An Application of Metathesis in Medicinal Chemistry.
ChainA
Resolution1.74 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LVH A L346 T347 L349 E353 L384 R394 F404 G521 L525 L37 T38 L40 E44 L75 R85 F95 G203 L207 MOAD: ic50=0.00000001M
PDBbind-CN: -logKd/Ki=9.40,IC50=0.40nM
BindingDB: IC50=1.3nM
External links
PDB RCSB:6suo, PDBe:6suo, PDBj:6suo
PDBsum6suo
PubMed31620239
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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