Structure of PDB 6st3 Chain A

Receptor sequence
>6st3A (length=210) Species: 9606 (Homo sapiens) [Search protein sequence]
PALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDG
QLVSQIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGR
TKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRI
FPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADE
RARAKVKYLT
3D structure
PDB6st3 Structure-Activity Relationship and Crystallographic Studies on 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors.
ChainA
Resolution2.426 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.29: hypoxia-inducible factor-proline dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LUW A R252 T296 Y303 Y310 H313 D315 R322 H374 V376 W389 F391 R57 T101 Y108 Y115 H118 D120 R127 H179 V181 W194 F196 MOAD: ic50=0.256uM
PDBbind-CN: -logKd/Ki=7.03,IC50=0.094uM
BS02 MN A H313 D315 H374 H118 D120 H179
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418 L-ascorbic acid binding

View graph for
Molecular Function
External links
PDB RCSB:6st3, PDBe:6st3, PDBj:6st3
PDBsum6st3
PubMed31751494
UniProtQ9GZT9|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)

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