Structure of PDB 6ssq Chain A

Receptor sequence
>6ssqA (length=239) Species: 9606 (Homo sapiens) [Search protein sequence]
SYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWD
KFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTR
YTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTET
GLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPK
ILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMME
3D structure
PDB6ssq Regulation of RXR-RAR Heterodimers by RXR- and RAR-Specific Ligands and Their Combinations.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K237 Q250 I251 P401 Q404 E405 E408 K68 Q81 I82 P232 Q235 E236 E239
BS02 754 A F221 C228 L259 L262 I263 F279 S280 F295 G384 V388 F52 C59 L90 L93 I94 F110 S111 F126 G215 V219 BindingDB: EC50=10nM,Ki=2587nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0048384 retinoic acid receptor signaling pathway
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ssq, PDBe:6ssq, PDBj:6ssq
PDBsum6ssq
PubMed31694317
UniProtP10826|RARB_HUMAN Retinoic acid receptor beta (Gene Name=RARB)

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