Structure of PDB 6sqr Chain A

Receptor sequence
>6sqrA (length=69) Species: 9685 (Felis catus) [Search protein sequence]
EEIVEPEFPHNAIEPCVICQTRPKNGCIVHGKTGHLMACFTCAKKLKKRN
KPCPVCRQPIQMIVLTYFP
3D structure
PDB6sqr Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain.
ChainA
Resolution2.18 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C438 C441 C461 C464 C16 C19 C39 C42
BS02 ZN A H452 H457 C475 C478 H30 H35 C53 C56
Gene Ontology
Molecular Function
GO:0042802 identical protein binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6sqr, PDBe:6sqr, PDBj:6sqr
PDBsum6sqr
PubMed32350255
UniProtQ7YRZ8|MDM2_FELCA E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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