Structure of PDB 6sqc Chain A

Receptor sequence
>6sqcA (length=424) Species: 9606,83333 [Search protein sequence]
MKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQ
VAATGDGPDIIFWAHDRFGGYAQSGLLAEITPAAAFQDKLYPFTWDAVRY
NGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMF
NLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLI
KNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSAVNYGVTVLPT
FKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPL
GAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVIN
AASGRQTVDAALAAAQTNAAAMSISPSALQDLLRTLKSPSSPQQQQQVLN
ILKSNPQLMAAFIKQRTAKYVANQ
3D structure
PDB6sqc Conformational editing of intrinsically disordered protein by alpha-methylation.
ChainA
Resolution2.28 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC A K1704 E1800 Y1844 W1919 K16 E112 Y156 W231
BS02 GLC A W1751 D1754 R1755 E1842 P1843 Y1844 W2029 W63 D66 R67 E154 P155 Y156 W341
BS03 ZN A M1689 D1744 K2075 M1 D56 K387
Gene Ontology
Molecular Function
GO:0003713 transcription coactivator activity
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0015144 carbohydrate transmembrane transporter activity
GO:1901982 maltose binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006974 DNA damage response
GO:0008643 carbohydrate transport
GO:0015768 maltose transport
GO:0034219 carbohydrate transmembrane transport
GO:0034289 detection of maltose stimulus
GO:0042956 maltodextrin transmembrane transport
GO:0055085 transmembrane transport
GO:0060326 cell chemotaxis
Cellular Component
GO:0000123 histone acetyltransferase complex
GO:0005634 nucleus
GO:0016020 membrane
GO:0030288 outer membrane-bounded periplasmic space
GO:0042597 periplasmic space
GO:0043190 ATP-binding cassette (ABC) transporter complex
GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:1990060 maltose transport complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6sqc, PDBe:6sqc, PDBj:6sqc
PDBsum6sqc
PubMed34163874
UniProtP0AEX9|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE);
Q92793|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

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