Structure of PDB 6sq8 Chain A

Receptor sequence
>6sq8A (length=486) Species: 531310 (Marinactinospora thermotolerans) [Search protein sequence]
PAMGYARRVMDGIGEVAVTGAGGSVTGARLRHQVRLLAHALTEAGIPPGR
GVACLHANTWRAIALRLAVQAIGCHYVGLRPTAAVTEQARAIAAADSAAL
VFEPSVEARAADLLERVSVPVVLSLGPTSRGRDILATPLRYREHPEGIAV
VAFTGTPKGVAHSSTAMSACVDAAVSMYGRGPWRFLIPIPLSDLGGELAQ
CTLATGGTVVLLEEFQPDAVLEAIERERATHVFLAPNWLYQLAEHPALPR
SDLSSLRRVVYGGAPAVPSRVAAARERMGAVLMQNYGTQEAAFIAALTPD
DHARRELLTAVGRPLPHVEVEIRDDSGGTLPRGAVGEVWVRSPMTMSGYW
RDPERTAQVLSGGWLRTGDVGTFDEDGHLHLTDRLQDIIIVEAYNVYSRR
VEHVLTEHPDVRAAAVVGVPDPDSGEAVCAAVVVADGADPDPEHLRALVR
DHLGDLHVPRRVEFVRSIPVTPAGKPDKVKVRTWFT
3D structure
PDB6sq8 Biocatalytic Synthesis of Moclobemide Using the Amide Bond Synthetase McbA Coupled with an ATP Recycling System.
ChainA
Resolution2.59 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T158 D201 Q297 E298 I398 N403 K483
Catalytic site (residue number reindexed from 1) T154 D193 Q289 E290 I390 N395 K475
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EQ2 A L202 G295 T296 A300 F301 L194 G287 T288 A292 F293
BS02 AMP A G271 A272 Q292 N293 T296 Q297 D377 R392 R407 K483 G263 A264 Q284 N285 T288 Q289 D369 R384 R399 K475
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016874 ligase activity

View graph for
Molecular Function
External links
PDB RCSB:6sq8, PDBe:6sq8, PDBj:6sq8
PDBsum6sq8
PubMed32337091
UniProtR4R1U5

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