Structure of PDB 6snp Chain A

Receptor sequence
>6snpA (length=568) Species: 9606 (Homo sapiens) [Search protein sequence]
EEWISGTYRKMEEGPLPLLTFATAPYHDQKPGTSGLRKKTYYFEEKPCYL
ENFIQSIFFSIDLKDRQGSSLVVGGDGRYFNKSAIETIVQMAAANGIGRL
VIGQNGILSTPAVSCIIRKIKAIGGIILTASHNPGGPNGDFGIKFNISNG
GPAPEAITDKIFQISKTIEEYAVCPDLKVDLGVLGKQQFDLENKFKPFTV
EIVDSVEAYATMLRSIFDFSALKELLSGPNRLKIRIDAMHGVVGPYVKKI
LCEELGAPANSAVNCVPLEDFGGHHPDPNLTYAADLVETMKSGEHDFGAA
FDGDGDRNMILGKHGFFVNPSDSVAVIAANIFSIPYFQQTGVRGFARSMP
TSGALDRVASATKIALYETPTGWKFFGNLMDASKLSLCGEESFGTGSDHI
REKDGLWAVLAWLSILATRKQSVEDILKDHWQKYGRNFFTRYDYEEVEAE
GANKMMKDLEALMFDRSFVGKQFSAVYTVEKADNFEYSDPVDGSISRNQG
LRLIFTDGSRIVFRLSGATIRLYIDSYEKDVAKINQDPQVMLAPLISIAL
KVSQLQERTGRTAPTVIT
3D structure
PDB6snp Structural basis for substrate and product recognition in human phosphoglucomutase-1 (PGM1) isoform 2, a member of the alpha-D-phosphohexomutase superfamily.
ChainA
Resolution2.75 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) R41 S135 H136 K148 D306 D308 D310 R311 G398
Catalytic site (residue number reindexed from 1) R37 S131 H132 K144 D302 D304 D306 R307 G394
Enzyme Commision number 5.4.2.2: phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A S135 D306 D308 D310 S131 D302 D304 D306
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004614 phosphoglucomutase activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0016868 intramolecular phosphotransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0033499 galactose catabolic process via UDP-galactose
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome
GO:1904724 tertiary granule lumen
GO:1904813 ficolin-1-rich granule lumen

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6snp, PDBe:6snp, PDBj:6snp
PDBsum6snp
PubMed32221390
UniProtP36871|PGM1_HUMAN Phosphoglucomutase-1 (Gene Name=PGM1)

[Back to BioLiP]