Structure of PDB 6sno Chain A

Receptor sequence
>6snoA (length=573) Species: 9606 (Homo sapiens) [Search protein sequence]
EWISGTYRKMEEGPLPLLTFATAPYHDQKPGTSGLRKKTYYFEEKPCYLE
NFIQSIFFSIDLKDRQGSSLVVGGDGRYFNKSAIETIVQMAAANGIGRLV
IGQNGILSTPAVSCIIRKIKAIGGIILTASHNPGGPNGDFGIKFNISNGG
PAPEAITDKIFQISKTIEEYAVCPDLKVDLGVLGKQQFDLENKFKPFTVE
IVDSVEAYATMLRSIFDFSALKELLSGPNRLKIRIDAMHGVVGPYVKKIL
CEELGAPANSAVNCVPLEDFGGHHPDPNLTYAADLVETMKSGEHDFGAAF
DGDGDRNMILGKHGFFVNPSDSVAVIAANIFSIPYFQQTGVRGFARSMPT
SGALDRVASATKIALYETPTGWKFFGNLMDASKLSLCGEESFGTGSDHIR
EKDGLWAVLAWLSILATRKQSVEDILKDHWQKYGRNFFTRYDYEEVEAEG
ANKMMKDLEALMFDRSFVGKQFSANVYTVEKADNFEYSDPVDGSISRNQG
LRLIFTDGSRIVFRLSGTGSAGATIRLYIDSYEKDVAKINQDPQVMLAPL
ISIALKVSQLQERTGRTAPTVIT
3D structure
PDB6sno Structural basis for substrate and product recognition in human phosphoglucomutase-1 (PGM1) isoform 2, a member of the alpha-D-phosphohexomutase superfamily.
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R41 S135 H136 K148 D306 D308 D310 R311 G398
Catalytic site (residue number reindexed from 1) R36 S130 H131 K143 D301 D303 D305 R306 G393
Enzyme Commision number 5.4.2.2: phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A S135 D306 D308 D310 S130 D301 D303 D305
BS02 G1P A S135 E394 S396 R521 S523 G524 T525 R533 S130 E389 S391 R514 S516 G517 T518 R526
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004614 phosphoglucomutase activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0016868 intramolecular phosphotransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0033499 galactose catabolic process via UDP-galactose
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome
GO:1904724 tertiary granule lumen
GO:1904813 ficolin-1-rich granule lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6sno, PDBe:6sno, PDBj:6sno
PDBsum6sno
PubMed32221390
UniProtP36871|PGM1_HUMAN Phosphoglucomutase-1 (Gene Name=PGM1)

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