Structure of PDB 6slt Chain A

Receptor sequence
>6sltA (length=528) Species: 1887 (Streptomyces albogriseolus) [Search protein sequence]
DNRIKTVVILGGGTAGWMTAAYLGKALQNTVKIVVLEAPTIPRIGVGEAT
VPNLQRAFFDYLGIPEEEWMRECNASYKMAVKFINWRTPGEGSPDPRTLD
DGHTDTFHHPFGLLPSADQIPLSHYWAAKRLQGETDENFDEACFADTAIM
NAKKAPRFLDMRRATNYAWHFDASKVAAFLRNFAVTKQAVEHVEDEMTEV
LTDERGFITALRTKSGRILQGDLFVDCSGFRGLLINKAMEEPFIDMSDHL
LCNSAVATAVPHDDEKNGVEPYTSSIAMEAGWTWKIPMLGRFGSGHVYSD
HFATQDEATLAFSKLWGLDPDNTEFNHVRFRVGRNRRAWVRNCVSVGLAS
CFVEPLESSGIYFIYAAIHMLAKHFPDKTFDKVLVDRFNREIEEMFDDTR
DFLQAHYYFSPRVDTPFWRANKELKLADSIKDKVETYRAGLPVNLPVTDE
GTYYGNFEAEFRNFWTNGSYYCIFAGLGLMPRNPLPALAYKPQSIAEAEL
LFADVKRKGDTLVESLPSTYDLLRQLHG
3D structure
PDB6slt Binding of FAD and tryptophan to the tryptophan 6-halogenase Thal is negatively coupled.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.19.59: tryptophan 6-halogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 A R158 R164 R157 R163
BS02 PO4 A H250 R401 H249 R400
BS03 TRP A V52 P53 H110 P111 F112 E358 Y454 Y455 E461 F465 W466 V51 P52 H109 P110 F111 E357 Y453 Y454 E460 F464 W465
BS04 AMP A G12 G13 A39 E197 M198 R232 L234 G11 G12 A38 E196 M197 R231 L233
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0004497 monooxygenase activity
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:6slt, PDBe:6slt, PDBj:6slt
PDBsum6slt
PubMed31589794
UniProtA1E280|TRP6H_STRAO Tryptophan 6-halogenase ThaL (Gene Name=thaL)

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