Structure of PDB 6slm Chain A

Receptor sequence
>6slmA (length=539) Species: 9606,10585,83333 [Search protein sequence]
KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQV
AATGDGPDIIFWAHDRFGGYAQSGLLAEITPAAAFQDKLYPFTWDAVRYN
GKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFN
LQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIK
NKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSAVNYGVTVLPTF
KGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLG
AVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINA
ASGRQTVDAALAAAQTNAAAMFKNPAERPRKLHELSSALEIPYDELRLNC
VYCKGQLTETEVLDFAFTDLTIVYRDDTPHGVCTKCLRFYSKVSEFRWYR
YSVYGTTLEKLTNKGISDLLIRCITCQRPLSPEEKQRHLDKKKRFHNIGG
RWTGRCIACWRRPRTETQVGSSGAAESSELTLQELLGEE
3D structure
PDB6slm Structure of High-Risk Papillomavirus 31 E6 Oncogenic Protein and Characterization of E6/E6AP/p53 Complex Formation.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.26: HECT-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC A K645 E741 Y785 W860 K15 E111 Y155 W230
BS02 GLC A W692 D695 R696 E783 P784 Y785 W970 W62 D65 R66 E153 P154 Y155 W340
BS03 ZN A C1103 C1106 C1139 C473 C476 C509
BS04 ZN A C1030 C1033 C1063 C1066 C400 C403 C433 C436
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0015144 carbohydrate transmembrane transporter activity
GO:0030165 PDZ domain binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006355 regulation of DNA-templated transcription
GO:0008643 carbohydrate transport
GO:0019049 virus-mediated perturbation of host defense response
GO:0039502 symbiont-mediated suppression of host type I interferon-mediated signaling pathway
GO:0039548 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
GO:0039648 symbiont-mediated perturbation of host ubiquitin-like protein modification
GO:0052150 symbiont-mediated perturbation of host apoptosis
GO:0055085 transmembrane transport
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6slm, PDBe:6slm, PDBj:6slm
PDBsum6slm
PubMed33115863
UniProtP0AEX9|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE);
P17386;
Q05086|UBE3A_HUMAN Ubiquitin-protein ligase E3A (Gene Name=UBE3A)

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