Structure of PDB 6sky Chain A

Receptor sequence
>6skyA (length=1412) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence]
GYPLEMLLHSLRVFVVDPECADDALGITQYLIKRGDEYLKRTPSFLAGYA
LSSLADLRVFLFKATKSKAQEFHAWFSKYLAAYDSPEFKDEGQKQAFRSI
TENAAHIRASGNAEKGTHESNLLLEILKDWGRENQLLNEPARDVALSMLC
GVFNIPPSSRLDVIETDEDAIKNGAVVWKSCSSQRLGGEYLAWAGRVLGR
SFAASGEVPEDLLRESQLQEYRRLSQGVGSSEEGLLNLIKSLTISGDCFT
AGLAEAALRTIVSDAISDNDHDLLSACQESLPEPLLIASNWDPYRTPEVF
SARALENPNWSQHLAIRLALSAPKIVTLRVLPPILSKVKGFAERAFPFVV
HLVLAYQLDKQQSAKRELSESLQEWLNFTSEPAKENLKLLINTILYLRTQ
PLPGESSIADRAHWLDVNMASAAAAATRCGMYKVALLFAELAAESTRSDI
LLEIFENIDDPDAYYGLSQDASLSTVLARLEYENDGAKSLAFRGAQYDSH
LRGRDLQSRQDCNALIKALSSLGLAGLSNSLLQSQSLDATFTTARKLEIW
NLPAPVNSDSWAVTVYKAYQSMYQAQELDTVRSMVHDGLKNTVRHLSSGS
LNTSVLRQQLGALAALTELDDILNVRDQSELQCTLATFEKRSKWMMSGRY
ADVSQILSCRETTLSMWSQRHNLRAAGLTSADARLVQIRGMLLSSDIFRF
HRARQETLNLSTALSDLIPSCESLGLSVDAAIKMEAANALWDHGEMISSI
RMLQAIDKDSSLKKQSVPLSRSDLLSKIGYQVSVARLESPDAIQKKYLEP
ALKELKGKIEGREAGQVFHQFAVFCDEQLQNPDSLEDLARLQNLKKGKDE
EVAQLKSHLAKAKQWQELDQQELRRVEQTRSEFLKLCIENYLLSLAASDE
HDNDALRFMALWLEKSEEEVANEVVKKWINKVPTRKFALLMNQLSSRLQD
HNTLFQKLLIDLVYRICVDHPYHGMYHIWTGARVAVSRQRATDKIAKALS
KNNKVSSIWPAIDQTSRVYHALAMDRDPTRYKSGQKVPIKNSPVGQNFLS
TMSNNPIPPPTLQIEVSANLDYSHVPMIHKFAPEMAIASGVSAPKILTAI
GTDGRKYKQLVKGGNDDLRQDAIMEQVFAAVSELLKLHRETRQRNLGIRT
YKVLPLTSSSGLIEFVSNTIPLHEYLMPAHERYYPKDLKGSQCRKEIANA
QTKNTETRIAVYRRVTERFHPVMRYFFMEYFPDPDEWFQKRTNYTRTTAA
ISMLGHVLGLGDRHGHNILLDHKTGEVVHIDLGVAFEMGRVLPVPELVPF
RLTRDIVDGMGITKTEGVFRRCCEFTLDALREEAASIQTILDSLRHDTLY
QWSISPVRMAKLQNSEADRAIEVVKKKLSKTLSVMATVNDLINQATSVSN
LAVLYSGWAAYA
3D structure
PDB6sky Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS A L2608 K2610 F2663 V2664 P2669 H2764 I2778 L1110 K1112 F1165 V1166 P1171 H1266 I1280
Gene Ontology
Molecular Function
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0044024 histone H2AS1 kinase activity
Biological Process
GO:0006281 DNA repair
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0006974 DNA damage response
GO:0016310 phosphorylation
GO:0019222 regulation of metabolic process
GO:0035556 intracellular signal transduction
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6sky, PDBe:6sky, PDBj:6sky
PDBsum6sky
PubMed31740028
UniProtG0S4S9

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